Patients were most commonly Caucasian (44.2%) or African American (43.4%) men with a median
age of 28 years at HIV diagnosis. HSV-2 seroprevalence at HIV diagnosis decreased from the period of
1996–2004 (48.8%) to 2005–2012 (30.1%; P < 0.01). Odds of HSV-2 seropositivity was significantly greater
for non-Caucasians (OR 2.19, 95% CI 1.33–3.60) and for HIV diagnosis between 1996 and 2004 (OR 2.06,
95% CI 1.29–3.27), with a trend observed for those age >30 years at HIV diagnosis (OR 1.73, 95% CI
0.94–3.18). A total of 81 (20.4%) patients developed STIs by ICD-9 codes, including 24 (6.1%) new genital
herpes diagnoses, during a median follow-up of 4.6 years. HSV-2 seroconversion occurred in 33 of 253
(13.0%) with an incidence rate of 5.07 per 100 person-years (95% CI 4.76–5.37).
Conclusion: Although HSV-2 seroprevalence at HIV diagnosis decreased over time, high-risk sexual behaviors
were ongoing as evidenced by the high proportion of new STI diagnoses and HSV-2 seroconversions.
Continued education to reduce risk behaviors is warranted to prevent acquisition and transmission of
STIs in HIV-infected persons