In UATPP, ultrasound pretreatment was given to ginger rhizome slurry prior to TPP and each of the parameters associated therewith was optimized using one factor at-a-time method. Optimization of power requirement for the maximum extraction of various gingerols was done by varying the power from 28 to 65 W for 10 min. Effect of duty cycle (30–100%) on extraction of gingerols was evaluated by subjecting 5% (w/v) of slurry prepared in distilled water at optimized power for 10 min. Further, optimization of extraction time (5–20 min) of sonication prior to TPP was carried out for maximum extraction of gingerols and later gingerol content was quantified by HPLC