This study showed that zebrafish were susceptible to I. multifiliis
in the skin and in the gills and were able to acquire immunity
against the parasite, similar to the conditions observed in other
freshwater fish species. Aquacultured fish such as channel catfish,
carp and rainbow trout are to this date highly affected by white spot
disease caused by I. multifiliis. The fish industry undergoes severe
economical losses due to this disease and no prophylactic means
are available even though the fish are able to acquire protection.
Since zebrafish are natural hosts for the parasite we have a unique
chance of elucidating the host/parasite interactions and investigate
the immunological factors responsible for protection using available
transgenic zebrafish lines. With these lines it may be possible
to determine the reaction and effect of specific cell types and factors
of the immune system. With this opportunity new knowledge
may lead to targeted vaccine development against I. multifiliis.