Since Cu is a redox-active metal, which acts as a catalyst in the
formation of ROS, Dávila Costa et al. (2011) compared the effects of
Cu on the growth, viability, morphology, and antioxidation ability
of the novel Cu-resistant strain A. tucumanensis DSM 45259 vs the
Cu-sensitive Amycolatopsis eurytherma. Interestingly, the increase
in ROS production in the former, from the basal level to the stress
conditions, was found to be less than in the Cu-sensitive strain.
Also, in the presence of Cu, A. eurytherma suffered inexorable
morphological alteration while A. tucumanensis DSM 45259
remained unaffected. Also the levels of the antioxidant enzymes
superoxide dismutase (SOD) and catalase (CAT), as well as the
levels of metallothioneins (MT), were all found to be greater in
A. tucumanensis DSM 45259 than in A. eurytherma.