As an alternative to traditional gels for the topical applications
of hydrophobic drugs, Koop et al. demonstrated that the
xanthan-galactomannan (X:G) hydrogels system with addition
of curcumin in microemulsion, exhibited a significantly higher
elastic response. In vitro skin permeation tests showed a more
pronounced lag time and more efficient permeation with their
novel delivery system [69]. Similarly, curcumin loaded chitin
nanogels (CCNGs) were developed, using biocompatible and
biodegradable chitin. Both chitin and curcumin are insoluble
in water but CCNGs developed by Mangalathillam et al. form a
very good and stable dispersion in water and their study suggested
that the formulated CCNGs have specific advantage for
the treatment of melanoma, the most common and serious
type of skin cancer, by effective transdermal penetration [70].
As an alternative to traditional gels for the topical applicationsof hydrophobic drugs, Koop et al. demonstrated that thexanthan-galactomannan (X:G) hydrogels system with additionof curcumin in microemulsion, exhibited a significantly higherelastic response. In vitro skin permeation tests showed a morepronounced lag time and more efficient permeation with theirnovel delivery system [69]. Similarly, curcumin loaded chitinnanogels (CCNGs) were developed, using biocompatible andbiodegradable chitin. Both chitin and curcumin are insolublein water but CCNGs developed by Mangalathillam et al. form avery good and stable dispersion in water and their study suggestedthat the formulated CCNGs have specific advantage forthe treatment of melanoma, the most common and serioustype of skin cancer, by effective transdermal penetration [70].
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