Spinosad is a bioinsecticide made from spinosyns, which is generated
as a fermentation product from the actynomycete species Saccharopolyspora spinosa (Mertz & Yao). This compound is an agonist of nicotinic acethylcholine receptors and
also interferes with receptors of c-aminobutiric acid (GABA) in the nervous system . Spinosad was initially considered safe for several non-target arthropods, and its use was allowed and expanded for crop protection , especially in organic production, but such perceived selectivity has been challenged.