We expected that the findings of our study
could help in better management of asphyxiated neonates.
We have not found any literature or standard text book
citing hyponatremia as the cause of perinatal asphyxia
Rather few literatures have demonstrated clearly in separate
studies that hyponatremia and hypocalcemia are the con-
sequences of perinatal asphyxia [1, 2]. In our study we
demonstrated that the hyponatremia and hypocalcemia
occur simultaneously in such neonates and they also have
significant correlation with their severity of asphyxia,
irrespective of their intra or post partum origin
Oxytocin was administered to mothers of 6% of total number of cases
in scheduled therapeutic doses as per protocol available
with the labour room.
The Correspondent probably overlooked that we have
excluded cases whose mothers had pre and post delivery
electrolyte abnormalities. The indications of caesarean section
were decreased scores of foetal biophysical profiles, suspected
intrauterine asphyxia or development of early foetal distress.
All the mothers who were delivered by caesarean section
received either spinal anaesthesia or epidural analgesia. All of
them received fluid during operation as per standard anaes-
thetic protocol. All other mothers delivered vaginally also
received fluid as per standard obstetric protocol. In none of the
cases any fluid or medication was given in excess of available
guideline. From different literatures and from our study we
found that a large percentage of the asphyxiated babies were
delivered by caesarean section [3]. So, it was our aim also to
find electrolyte status in those asphyxiated neonates soon
after birth. If some outcome of electrolyte status is influenced
by standard interventions during delivery or operations, the
electrolyte status we found in babies after such deliveries
invariably indicated that they require some definite manage-
ments and caesarean asphyxiated babies are in greater
numbers than their normally delivered counterpart. So, we
do not found it is necessary to give special importance to
draw a line between normally delivered and caesarean
babies.
All the standard text books and literatures explained that
perinatal asphyxia and metabolic acidosis go hand in hand.
So, cord blood pH was not considered in our study. This study
never aimed at finding out the aetiology of the abnormalities
in electrolyte status in asphyxiated babies. May be acidosis is
one of the contributor of increased potassium level in cases.
May be the transient hyperinsulinism which sometimes
develop in perinatal asphyxia influence the potassium level
among cases [4]. We hope researchers are seriously thinking
to find the etiologic correlations between electrolyte changes
and perinatal asphyxia and from the correspondent’s letter it
is clear that we have raised such queries in others mind. This
might be a success of our study. We do not know what
literature guided the correspondent to state that in birth
asphyxia, dilutional hyponatremia causes lower albumin
level. Correction of total calcium level for albumin level is
only done when it is so indicated. And perinatal asphyxia is
never such indication. So we do not find it necessary to
estimate albumin.
We expected that the findings of our study
could help in better management of asphyxiated neonates.
We have not found any literature or standard text book
citing hyponatremia as the cause of perinatal asphyxia
Rather few literatures have demonstrated clearly in separate
studies that hyponatremia and hypocalcemia are the con-
sequences of perinatal asphyxia [1, 2]. In our study we
demonstrated that the hyponatremia and hypocalcemia
occur simultaneously in such neonates and they also have
significant correlation with their severity of asphyxia,
irrespective of their intra or post partum origin
Oxytocin was administered to mothers of 6% of total number of cases
in scheduled therapeutic doses as per protocol available
with the labour room.
The Correspondent probably overlooked that we have
excluded cases whose mothers had pre and post delivery
electrolyte abnormalities. The indications of caesarean section
were decreased scores of foetal biophysical profiles, suspected
intrauterine asphyxia or development of early foetal distress.
All the mothers who were delivered by caesarean section
received either spinal anaesthesia or epidural analgesia. All of
them received fluid during operation as per standard anaes-
thetic protocol. All other mothers delivered vaginally also
received fluid as per standard obstetric protocol. In none of the
cases any fluid or medication was given in excess of available
guideline. From different literatures and from our study we
found that a large percentage of the asphyxiated babies were
delivered by caesarean section [3]. So, it was our aim also to
find electrolyte status in those asphyxiated neonates soon
after birth. If some outcome of electrolyte status is influenced
by standard interventions during delivery or operations, the
electrolyte status we found in babies after such deliveries
invariably indicated that they require some definite manage-
ments and caesarean asphyxiated babies are in greater
numbers than their normally delivered counterpart. So, we
do not found it is necessary to give special importance to
draw a line between normally delivered and caesarean
babies.
All the standard text books and literatures explained that
perinatal asphyxia and metabolic acidosis go hand in hand.
So, cord blood pH was not considered in our study. This study
never aimed at finding out the aetiology of the abnormalities
in electrolyte status in asphyxiated babies. May be acidosis is
one of the contributor of increased potassium level in cases.
May be the transient hyperinsulinism which sometimes
develop in perinatal asphyxia influence the potassium level
among cases [4]. We hope researchers are seriously thinking
to find the etiologic correlations between electrolyte changes
and perinatal asphyxia and from the correspondent’s letter it
is clear that we have raised such queries in others mind. This
might be a success of our study. We do not know what
literature guided the correspondent to state that in birth
asphyxia, dilutional hyponatremia causes lower albumin
level. Correction of total calcium level for albumin level is
only done when it is so indicated. And perinatal asphyxia is
never such indication. So we do not find it necessary to
estimate albumin.
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