It is generally accepted that research in biology today requires both computer and experimental equipment equally well. Information achieved from enormous exhaustive data have greatly contributed to the paradigm shift in biology. Biology or life sciences are no longer restricted to wet-bench experiments. In silico and in vitro / in vivo analyses together will push back the frontiers of life sciences. In particular, researchers in life science must rely on computers to analyze nucleotide sequence data accumulating at a remarkably rapid rate. Actually, this triggered the birth and development of information biology. DDBJ Center is to play a major role in carrying out research in information biology and to run DDBJ operation in the world.