shows a
general flow chart for mass spectrometry. Each
analytical technique offers different advantages and
limitations in terms of instrument sensitivity,
resolution, mass accuracy, dynamic range and
throughput: a number of techniques are needed to
analyse the entire proteome or metabolome. In
proteomics, several ionisation techniques have
improved the way proteins are characterised and
sequenced, in particular, electrospray ionisation
(ESI) and matrix-assisted laser desorption/