this invention also provides transgenic plants and progeny seed comprising the transgenic plants cell where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein, and enhanced seed oil. Pfam domain anal. was used to identify candidate proteins with desirable traits.Two hundred four nucleic acids are identified wherein gene over-expression or gene suppression results in improved traits, and addnl.18,839 protein homologs identified by BLAST searching of public databases. Also disclosed are methods are manufg. transgenic seed and plants with enhanced traits.