Telomerase is made of the catalytic subunit of human telomerase reverse transcriptase (hTERT) and telomerase RNA (hTR). Overexpression of a 27 kDa C-terminal polypeptide of hTERT (hTERTC27) carried by recombinant AAV can prevent the growth of human U87-MG glioblastoma cells in nude mice by increasing necrosis, apoptosis and neutrophil infiltration, and by decreasing microvascular density [90].