3. Results
3.1. Forced swim test
3.1.1. The influence of caffeine on antidepressant activity of tested drugs in FST
3.1.1.1. Effect of combined administration of caffeine and moclobemide in FST
The effect of the combined administration of caffeine and moclo-bemide on the total duration of the immobility time in mice is shown in Fig. 1A. Caffeine (5 mg/kg) injected in combination with moclobemide (1.5 mg/kg) significantly reduced the immobility time in the FST in mice (Fig. 1A). Moclobemide (1.5 mg/kg) and caffeine (5 mg/kg) given alone had no effect on the immobility time (Fig. 1A).