Topical negative pressure (TNP) therapy has emerged as a high-technology, microprocessor-controlled physical
wound-healing modality. Complex effects at the wound—dressing interface following application of a controlled
vacuum force have been documented. These include changes on a microscopic, molecular level and on a
macroscopic, tissue level: interstitial fluid flow and exudate management, oedema reduction, effects on wound
perfusion, protease profiles, growth factor and cytokine expression and cellular activity, all leading to enhanced
granulation tissue formation and improved wound-healing parameters. Primary indications for clinical use have
been documented and include traumatic wounds, open abdominal wounds, infected sternotomy wounds, wound
bed preparation, complex diabetic wounds and skin-graft fixation. Whilst this therapy now forms an essential
part of the wound healing armamentarium, extensive clinical trials are recommended to confirm efficacy and
delineate its optimum use.