Han et al[135], found that a pretreatment with naringenin-7-O-glucoside increased NQO1, ERK and phosphorylation and translocation of Nrf2 to the nucleus in H9c2 cardiomyocytes, as well as, upregulating the mRNA expression of GCLC and GCL modifier[135], thus inducting endogenous antioxidant enzymes.