7, 9 We previously found11 that most patients with upper airway inflammatory disorders and cough have laryngeal hyperresponsiveness (LHR), which is a paradoxical inspiratory vocal cord adduction on histamine inhalation challenge that is consistent with an irritable larynx. Such reflex laryngoconstriction was reflected by a decrease in inspiratory airflow rates, particularly the maximum midinspiratory airflow rate (MIF50).