The MSF MDR-TB programme has achieved good results [17]. However, the acceptability and accessibility of this model of care was not known. Although the Stop TB Strategy highlights the importance of patient-centred models of care [18] research on patients’ opinions and preferences is scarce. We conducted a qualitative study examining the experience of patients and key stakeholders with the aim of determining the acceptability and accessibility of the MDR-TB home-based treatment and care programmes in Kitgum and Lamwo. We also aimed to learn lessons from the programme implementation and obtain information to guide the development and future implementation of this model of care.