These inconsistent results for 6-OHDA studies could be due to differences in the locations of 6-OHDA injections, namely SN pars compacta (SNpc) vs. medial forebrain. Although all three 6-OHDA studies administered doses above the physiological range, Ferraz et al., [78] used the highest dose, supporting the conclusion that doses in the physiological range are more effective. Also, the duration of Ferraz et al.’s [78] study was longer than the others, which could imply that E2 only protects for a limited time in the 6-OHDA model.
These inconsistent results for 6-OHDA studies could be due to differences in the locations of 6-OHDA injections, namely SN pars compacta (SNpc) vs. medial forebrain. Although all three 6-OHDA studies administered doses above the physiological range, Ferraz et al., [78] used the highest dose, supporting the conclusion that doses in the physiological range are more effective. Also, the duration of Ferraz et al.’s [78] study was longer than the others, which could imply that E2 only protects for a limited time in the 6-OHDA model.
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