viable bacteria from the hemolymph was noted, and these live
bacteria moved and accumulated in hepatopancreas, gills and
lymphoid organ [46]. The live bacteria were rapidly cleared from
hemolymph by the cellular immune responses including phagocytosis
and encapsulation [47,48].
Besides humoral immune response mediated by proPO system,
the cellular immune response e phagocytosis related with Ran
gene was also investigated in the present study. Phagocytosis is an
actin-dependent process to protect host against microbial pathogens
[49] through the phago-lysosomal pathway. Ran gene was
characterized in M. japonicus, and this gene regulates shrimp