Duloxetine hydrochlorideentericcoatedpelletswereformulatedusingfluidizedbed.
Three separatelayers,thedruglayer,thebarrierlayer,andtheentericlayer,werecoatedontothe
inert corepellets.Thepelletswereoptimizedwiththeacidresistanceanddrugreleaseinsimulated
intestinal fluidastheprocessparameters,usingthe TaguchiL9 orthogonal array.