infants, school and preschool children. Regarding infants interruption of "mother-child" bond" is related with negative implications for the further psychological development. Similarly, preschool children are vulnerable to stress since they are more dependent on their parents, have greater needs and experience fear for frequent blood transfusions or administration of chelation. Older hospitalized children also experience lack of their personal space or lack of friends and anxiety for the success of therapeutic intervention. The existence of prior separation experience from their parents or other stressful and traumatic experiences related with emotional deprivation are also factors that trigger psychological distress in children.23-29