Layered double hydroxides can be regarded as a class of materials
that are simple to synthesize in the laboratory. In this study,
Ni–Al(NO3) LDH was employed as a nano-sorbent for the
separation and pre-concentration of MFA prior to determination
by spectrophotometry. It was found that Ni–Al(NO3) LDH showed
a good adsorption capacity for MFA, and the retained analyte can
be easily stripped with NaOH solution. This method is simple,
accurate with good recovery and low detection limit, repeatable
and matrix-independent at the low levels. The presented method,
which greatly improves the enrichment factor, can be applied for
the determination of MFA in various samples with complicated
matrices involving pharmaceutical wastewater and biological
samples. Moreover, the method represents a low cost, sensitive
and environment-friendly technique in the area of pharmaceutical
monitoring that can be recommended for the routine analysis of
MFA in quality control laboratories.