3.3. Angiogenic parameters
The mean VEGF value in diabetic rats’ retinae showed more
than 4-fold increase than that of non-diabetic rats (p < 0.0001).
TC significantly reduced VEGF in treatment group as compared to
diabetic control group (p < 0.001) (Fig. 2).
A sharp increase in PKC value occurred in diabetic group over
24 weeks of diabetes. However, TC treated rats exhibited about
2-fold reduction in PKC (p < 0.0001) as compared to untreated
group