Successful wetland restoration is frequently constrained by the absence of persistent attention to the whole remedial process. The paper put forward a holistic method to restore the lacustrine wetland ecosystem. Yilong Lake wetland, one of the nine largest lakes of the Yun-Gui Plateau in China, was used as a case study. A modified (Pressure-State-Response) PSR model was presented to establish a comprehensive indicator system and to explain the ecological sustainability. Ecosystem sustainability and water quality were set as the general restoration target and the constraint restoration target, respectively, that makes the restoration goals not only contains the whole ecosystem but also the key individual parts. Two restoration goals (high and low)
were set based on the cluster analysis of the historical data from 1952 to 2006. Different restoration levels give the decision makers and managers flexible options to restore the ecosystem based on the actual demand and practical capacity. Three restoration scenarios about the water replenishment and pollutant reduction were set to improve the ecological condition. The results showed that the integrated restoration measures according to water quantity and water quality can feasibly achieve the prescribed restoration levels. The paper gives the decision makers a holistic method to solve problems in lacustrine wetland restoration process.