The global evaluation of the changes of volatile compounds according to their origin indicates that the application of the most intense treatment conditions did not increase the level of compounds from Maillard and lipid oxidation reaction. In fact, treatments at 300 MPa and 50 and 80 °C showed the highest levels of these volatile compounds and concretely milk processed at 300 MPa and 80 °C showed the highest levels of volatiles from the Maillard reaction. Specific changes that occur at that pressure conditions could explain these results.