continuous activity monitoring where patients spend less time walking and standing than healthy controls.
In addition to the impact on functional status, physical inactivity is associated with a reduced health-related quality of life (HR-QoL) and contributes to loss of muscle mass, increased systemic inflammation, osteoporosis, and cardiovascular disease, all comorbidities of chronic obstructive pulmonary disease (COPD).
Consequently, it becomes a part of a vicious cycle of physical inactivity and changes in body composition that affect physical performance.