ontinuous exposure of the pituitary fragments at 10°C or 20°C to 10 nM sGnRH-A resulted in an initial peak of GtH-II release followed by desensitization to further sGnRH-A stimulation. This biphasic GtH-II response was not as clear at 1 nM dosage, because a rebound in GtH-II release occurred following the initial desensitiza- tion. There was, however, no clear influence of temperature on the GtH-II release pattern in response to continu- ous sGnRH-A treatment. These results provide evidence for direct influences of temperature on basal GtH-II release and pituitary responsiveness to GnRH in common carp. COMP BIOCHEM PHYSIOL 114A;4:341-347, 1996.