Comparative case studies: Three STEMI patients with angina pectoris were admitted to hospital. Two patients were diagnosed with anterior wall myocardial infarction (AWMI) while the other was diagnosed with inferior wall myocardial infarction (IWMI). All of them received emergency cardiac care (ECC) with door-to-balloon time not greater than 90 minutes. After angioplasty with stent placement was performed, cardiogenic shock was detected in the first patient who received intra-aortic balloon pump support later. After thrombolytic therapy, dyspnea, ST-elevation and hypotension were detected in the second patient who was then treated with mechanical ventilation and transferred to Khon Kaen hospital. A 6 cm. by 6 cm. hematoma at puncture site was found in the third patient. All of them received holistic nursing care corresponding to the results of Gordon’s 11 Functional Health Pattern assessment. The result shows that nursing care could solve fourteen patient-reported problems such as pain, low cardiac output, dyspnea, fever, prolonged intra-aortic balloon pump support, hematomas and electrolyte imbalance. All three patients recovered and were discharged by the doctor with home medications. Follow-up visits were scheduled at the hospital 2 weeks after the discharge. Early reperfusion therapy could preserve myocardial viability and reduce mortality in patients with STEMI. Therefore, nurse practitioners should be able to interpret the results of the patient’s EKG, recognize typical signs and symptoms of STEMI in screening test, make a decision, achieve interdisciplinary collaboration, manage the patient who requires emergency interventions, explain treatment plans to the patients as well as teaching self-care practice and behavioral modification skills when the patients are discharged.