Although integrated building automation systems have become increasingly popular, an integrated system which includes remote control technology to enable real-time monitoring of the energy consumption by energy end-users, as well as optimization functions is required. To respond to this common interest, the main aim of the paper is to present an integrated system for buildings’ energy-efficient automation. The proposed system is based on a prototype software tool for the simulation and optimization of energy consumption in the building sector, enhancing the interactivity of building automation systems.The system can incorporate energy-efficient automation functions for heating, cooling and/or lighting based on recent guidance and decisions of the National Law, energy efficiency requirements of EN15232 and ISO 50001 Energy Management Standard among others. The presented system was applied to a supermarket building in Greece and focused on the remote control of active systems.