Perfusion imaging with dynamic susceptibility contrast (DSC)-MRI is based on the principles of tracer kinetic modeling to assess the cerebral microvasculature.[5] In DSC perfusion imaging, a contrast agent is injected into the blood and monitored as it passes through the microvasculature. The vasculature is a key feature in the histopathology diagnosis of gliomas and permits imaging associations with grade through perfusion-weighted imaging. Blood vessels are present in higher numbers within tumors than in normal brain tissue, and they tend to have a larger volume. In general, higher-grade tumors also tend to have higher blood volume. In higher-grade tumors, the degradation and remodeling of extracellular matrix macromolecules results in loss of blood-brain barrier (BBB) integrity,[6,7] which is seen as contrast leakage or enhancement.