Outcome Definitions
SMI in offspring was defined as schizophrenia or no affective psychosis, bipolar disorder (I or II) or major depressive disorder. Because the definitions of bipolar spectrum and minor depression are broad, these conditions were not counted as SMI. To test whether familial risk extends beyond the disorder diagnosed in the parent, we also defined “other SMI” as a psychotic or major mood disorder different from the diagnosis of the parent of the high-risk offspring (e.g., if the parent of high-risk offspring had schizophrenia, other SMI was defined as bipolar or major depressive disorder).