OXIDANTS AND ANTIOXIDANTS
preliminary evidence that such protective action may be exerted by selenoproteins, identifying
a novel function of selenoproteins in defense against peroxynitrite.
Another topic addressed is the modification of proteins by mixed disulphide formation with
glutathione, called glutathiolation (see Thomas & Sies, 1991). Dafre, Sies & Akerboom (1996)
examined the properties of protein S-thiolation and regulation of microsomal glutathione
transferase activity by the glutathione redox couple.
Studies from the author's laboratory were generously supported by the National Foundation for Cancer
Research, Bethesda, by the Deutsche Forschungsgemeinschaft, and by the Jung-Stiftung fur Wissenschaft
und Forschung, Hamburg.