Monitoring the evolution was carried out at intervals of 1, 3, 6 and 12 months after
study entry. Was developed a rigorous asthma management plan.
Have been clearly established investigation methods: history; clinical examination;
paraclinical explorations (spirometry, pulseoximetry, total and specific IgE determination,
determination of acute phase reactants erythrocyte sedimentation rate -ESR, fibrinogen
and C-reactive protein); methods of statistical processing of data; methods for determining