Table 1: Methodological problems of Quality of Life (QOL) evaluation in the elderly
• Higher proportion of illiteracy as compared to younger patients
• Presence of cognitive disorders with difficulty to understand QOL questionnaires
• Presence of comorbidities potentially confusing the real impact of cancer and treatment on QOL
• Use of QOL instruments needs validation in elderly patients
• Analysis of QOL data from subgroups of elderly patients enrolled in clinical trials without upper age limit suffer from selection bias.