Glutathione pills help to whiten the skin in a couple of different ways. Melanin is the pigment that gives our skin its color, produced by the activation of the enzyme Tyrosinase. GSH binds to Tyrosinase and helps prevent the enzymatic pathways from producing melanin. The second is a much more important role. GSH helps to prevent the activation of Tyrosinase by reducing free radicals in the body that can activate it and cause an increase in melanin production.