therefore seems appropriate to consider the risks of prescribing PPIs to individuals at risk for C difficile, including immunocompromised, elderly, hospitalized patients and those taking cyclic antibiotics. These concerns have led the US Food and Drug Administration (FDA) to issue a safety announcement regarding the use of PPIs and incidence of C difficile, stating that a diagnosis of C difficile should be considered for people taking PPIs who develop diarrhea that does not improve.