In vitro skin penetration study showed that curcumin- soybean
phospholipids-loaded liposomes can significantly endorse
drug permeation and deposition and also inhibited the growth
of melanoma cells to a greater extent. These results suggest
that curcumin-soybean phospholipids-loaded liposomes may
act as a transdermal carrier for curcumin in cancer treatment
[66]. Earlier, Wang et al. developed doxorubicin (DOX)-loaded
long circulating liposomes combined with curcumin (CUR)
(DOX-CUR-LCLs), as a novel formulation for cancer treatment.
Cytotoxicity evaluation showed that DOX-CUR-LCLs had a significantly
higher antitumor activity than other DOX preparations.
These observations suggest that this novel DOX-CURLCLs,
combination of DOX and CUR administered in long-circulating
liposomes, could possibly improve antitumor activity
[67].