This paper describes an intervention, Depression CARE for PATients at Home (Depression CAREPATH), designed specifically for use in home healthcare in managing depression as part of ongoing care for medical and surgical patients. The CAREPATH intervention was designed to be delivered by nurses, physical therapists and primary providers in the home. Training occupational therapists and other care providers to assist in the delivery further strengthens the intervention. The paper describes the developmental process, as well as the major components of the intervention including a depression care management protocol and resources for agencies to use to implement and support the use of the protocol in routine care. The paper also provides preliminary evidence of the feasibility of using the Depression CAREPATH effectively.