For example, Sclafani et al. have shown that orosensory factors play a role in the approach to food and in the reinforcement of food intake behaviors. Post-ingestive factors have also been shown to influence classical conditioning and taste preferences, which may relate to food reinforcement.
For example, mice lacking the ability to transduce sweet taste signals develop a strong preference for sucrose, but not sucralose , suggesting that the energy content of the solution and not the taste mediated its reinforcing properties