Reserpine is an antihypertensive drug that cuases depletion noradrenaline,catecholamine and serotonin stores resulting in reduction in BP, bradycardia and CNS depression. Decrease in cardiac output and peripheral resistance result in hypotensive effec
Absorption: Readiry absorbed from the GI tract, bioavailability about 50%
Distribution: Crosses the blood brain barrier and appears in breast milk . 95% bound to plasma proteins.
Metabolism: Extensive metabolism
Excretion: About 8% excreted in urine as metabolites and about 60% is excreted in faeces,mainly unchanged.