This review is an analysis of qualitative research studies that were focused on the complex factors and processes that influence self-care. Qualitative meta-synthesis has been used to understand various aspects of health around disease management and, importantly, is not dependent on using studies that self-identify (eg, via titles and abstracts) as being related only to “self-care.” This is vital when reviewing qualitative research of HF because studies are often framed in general terms (eg, “patient experiences”) but may contain themes and data relating to self-care.