9. All patients in our study responded favorably to therapy with inhaled
corticosteroids that which reconfirms the therapeutic efficacy of the ICS. Knowledge by
the pediatrician of the progress in delimiting the fundamentals of pharmacology of
glucocorticoids, especially transactivation and transrepression concepts and cofactor
recruitment led to a better understanding of the molecular mechanisms by which
glucocorticoids suppress inflammation and of necessity of this therapy. It is imperative to
establish a school for parents to handle background therapy.
10. Although the findings of this study suggest that there is little difference between
the effectiveness of a leukotriene receptor antagonist (LTRA) and an inhaled corticosteroid
(ICS) as first-line therapy control between an LTRA and beta2-agonist long-action as add-on
medication for ICS, caution is needed in interpreting these results.