Two methods are described for the simultaneous determination of rosiglitazone maleate (ROS) and gliclazide (GLZ) in binary mixture. The first method was based on spectrophotometric method by using absorption correction method, correction of absorbance for estimation of GLZ. Two wavelengths, 229 nm where both the drugs having absorbance and other 320nm (␣max of ROS) where ROS has absorbance but GLZ shows no interference were selected for estimation of both drugs using methanol as solvent. The linearity obtained in the range of 2-12 μg/mL and 4-24 μg/mL for ROS and GLZ, respectively. The second method was based on HPLC, separation of two drugs on the reversed phased column C18 at ambient temperature using a mobile phase consisting of acetonitrile:methanol:water (40:30:30 v/v, pH adjusted to 3.0 with orthophosphoric acid) at the flow rate of 1 mL/min. Quantitation was achieved with UV detection at 240 nm based on peak area with linear calibration curves at concentration ranges 1-10 μg/mL and 20-100 μg/mL for ROS and GLZ, respectively. No chromatographic interference from the tablet excipients was found. Both methods were validated in terms of accuracy, precision, ruggedness, limit of detection and limit of quantitation. The high recovery and low coefficients of variation conforms the suitability of the methods for simultaneous analysis of two drugs in combined tablets. Statistical analysis proves that the methods were found to be suitable for the routine quality control analysis in pure and pharmaceutical dosage forms.