In vitro digestion of raw starch granules by α-amylases from the rice weevil, Sitophilus oryzae (L.), was studied. Digestion of starch granules isolated from ball-milled cereals, especially corn and wheat, was extremely slow. Relative to intact starch granules of rice, corn, and wheat, gelatinized samples were 550-, 2000-, and 3300-fold, respectively, more susceptible to enzyme action. Among commercial starch samples tested, granular potato starch was most resistant to α-amylases from S. oryzae. Relative to granular potato