Fig. 7. 2-MCA inhibited growth and induced apoptosis in
COLO 205 xenograft. Animals with pre-established tumors
(n 8/group) were injected intratumorally with the indicated dosages of 2-MCA. Tumor volumes were monitored
by calipers and apoptosis was determined by TUNEL
assay. (a) Left, representative tumor-bearing nude mice
from the control (upper part) and 20 mg/kg/day of 2-
MCA-treated (lower part) groups. (a) Right, 2-MCA
induced apoptosis in COLO 205 xenograft by TUNEL
assay. Representative TUNEL assay of tumors from
the control (upper part) and 20 mg/kg/day of 2-MCAtreated (lower part) groups. (b) Mean of tumor volume
recorded at the indicated number of days after initiation of
treatment. 2-MCA, 2-methoxycinnamaldehyde.