To uncover the
candidate genes representing Thai-specific CNVs, the top 20
genes showing the greatest difference in frequency between each
population pair were chosen, which resulted in a non-redundant
list of 35 genes (Table S4 in File S1; p,0.0002). Hierarchical
clustering analysis (HCA) was performed on the scaled frequency
data of these gene-overlapping CNVs to group the most similar
population together based on frequencies. Although these CNVs
were picked to highlight the difference between Thai and
HapMap3 populations, the populations that showed the closest
relationship to Thais were JPT, CHB, and CHD (Figure 3). Based
on the HCA results, Asian populations were still the most similar
to each other. Populations with European and African ancestries
from HapMap3 samples were placed in a different clade from
Asian populations. Hence, cautions should be taken when
To uncover the
candidate genes representing Thai-specific CNVs, the top 20
genes showing the greatest difference in frequency between each
population pair were chosen, which resulted in a non-redundant
list of 35 genes (Table S4 in File S1; p,0.0002). Hierarchical
clustering analysis (HCA) was performed on the scaled frequency
data of these gene-overlapping CNVs to group the most similar
population together based on frequencies. Although these CNVs
were picked to highlight the difference between Thai and
HapMap3 populations, the populations that showed the closest
relationship to Thais were JPT, CHB, and CHD (Figure 3). Based
on the HCA results, Asian populations were still the most similar
to each other. Populations with European and African ancestries
from HapMap3 samples were placed in a different clade from
Asian populations. Hence, cautions should be taken when
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