Therewereno significant differences in the levels of
serumcalcium, phosphorus, alkaline phosphatase, growth hormone, insulin-like growth hormone-1, insulin-like
growth hormone binding protein-3, and cross-linked N-teleopeptide of type I collagen among the three groups.
This is the first study to demonstrate the effect of the long-term addition of PK orMK-4 to the control diet on body
composition and serumparameters in an in vivo systemusing rats. Further studies on themechanismof vitamin K
supplementation in the regulation of bone metabolismwould provide valuable data on the prevention of lifestylerelated
disorders, including osteoporosis.