The antimutagenicity test, the DMSO extract of Sesbania javanica Miq. flower strongly
inhibited AFB
1 and B(a)P induced mutagenicity,
by S. typhimurium tester strains TA98 and TA100
(Table 1). The relationship between the percentage of inhibition versus the extract concentration was analyzed by simple regression. Analyses were carried out using Microsoft Excel. The
inhibitory effect of Sesbania javanica Miq. flower
extract on AFB
1 (r=0.894; p≤0.01) and B(a)P
(r=0.813; p≤0.01) for Salmonella TA 98 was obtained. The inhibitory effect of the Sesbania
javanica Miq. flower extract on AFB1 (r=0.816;
p≤0.01) and B(a)P (r=0.803; p≤0.01) for Salmonella TA 100, increased with an increasing concentration of flower extract. The isolated major
flavonoid (207 µg/plate) also possessed a strong
antimutagenic effect (>70%) against AFB1 and