after 1 year of Look AHEAD ILI (22), participants with type 2 diabetes had greatly improved levels of peripheral insulin sensitivity, fasting glucose, and FFAs in parallel to significant weight and fat loss, improvement in adipose tissue distribution, and decrease in hepatic fat. The changes in the peripheral insulin sensitivity were best predicted by the overall change in weight and fat mass; the only regional fat measure independently predicting metabolic improvements was the decrease in hepatic fat