Pack clothing using the time-honored "roll" technique. Lay two or three items on top of one another, smooth to flatten, and roll them up like you would a sleeping bag to save space and prevent wrinkles. For added wrinkle insurance, place a sheet of heavy tissue or packing paper between items of clothing before rolling. Don't worry about wrinkle-prone garments; most hotel/motel/inn rooms have an iron and board in the closet for your needs, not to mention a hotel laundry service.