Indomethacin treated group had shown large erosion area in the mucosal epithelium with presence of crypts; ulcer pits and damage muscularis mucosal layer were observed.
Treatment with SCC can protected the gastric tissue from the action of indomethacin damage cell.
At the concentration of 100 and 250 mg/kgBW of SCC treated group the rupture at various portions of the mucosal epithelial layer was presented and the crypts in the mucosal glandular layer and slightly disrupted muscle layer similar results to omeprazole and vitamin C treatment group were showed.
SCC at 500 mg/kgBW treated groups significantly reduced the damage of gastric cell and protected gastric cell as well as the normal control group.